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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T10396 | ATM Inhibitor-1 | ATM/ATR | |
ATM Inhibitor-1 is a highly potent, selective and orally active ATM inhibito (IC50: 0.7 nM) anti-tumor activity. It shows weak activity against mTOR (IC50, 21 μM), DNAPK (IC50, 2.8 μM), PI3Kα (IC50, 3.8 μM), PI3Kβ (IC50,... | |||
T5092 | AIM-100 | AIM100 | ACK |
AIM-100 is a Ack1 inhibitor (IC50: 24 nM). | |||
T62684 | ATM Inhibitor-5 | ||
ATM Inhibitor-5 [formula (1)] is a potent inhibitor of the serine/threonine protein kinase ATM. | |||
T3824 | Jaceosidin | Apoptosis , BCL , COX , UGT | |
Jaceosidin has anti-oxidative activity. Jaceosidin has anti-inflammatory activity, also a microglial inhibitor with anti-neuroinflammation activity. aceosidin has anticancer activity, modulates the ERK/ATM/Chk1/2 pathway... | |||
T63279 | ATM Inhibitor-2 | ||
ATM Inhibitor -2 is a potent and selective inhibitor of ATM (IC50<1 nM). | |||
T63714 | ATM-IN-1 | ||
ATM-IN-1 is a potent inhibitor of ATM. ATM-IN-1 has shown research potential in cancer and neurological diseases. | |||
T63317 | ATM Inhibitor-4 | ||
ATM Inhibitor -4 is a selective and potent ATM inhibitor (IC50: 0.32 nM) that strongly inhibits the activity of the PI3K kinase family and exhibits good metabolic stability. ATM Inhibitor -4 completely inhibits mTOR at 1... | |||
T79306 | ATM Inhibitor-9 | ATM/ATR | |
ATM Inhibitor-9 (Compd 7a) is a potent inhibitor of ATM kinase, exhibiting an IC50 value of 5 nM, and is utilized in cancer research [1]. | |||
T35942 | AZ 5704 | ||
Potent and selective ATM kinase inhibitor (IC50 = 0.6 nM in an enzyme inhibition assay). Exhibits > 600-fold selectivity for ATM over other kinases. Inhibits ATM kinase in an in vitro cellular assay (IC50 = 0.33 μM). Pot... | |||
T79305 | ATM Inhibitor-8 | ATM/ATR | |
ATM Inhibitor-8 (Compound 10r) is a potent, selective, and orally active inhibitor of ATM, exhibiting anti-tumor activity [1], characterized by an IC50 value of 1.15 nM. | |||
T60273 | Mirin | ||
Mirin is a potent Mre11-Rad50-Nbs1 (MRN) complex inhibitor. Mirin prevents MRN-dependent activation of ATM (IC 50 =12 μM) without affecting ATM protein kinase activity, and it inhibits Mre11-associated exonuclease activi... | |||
T78711 | A011 | ATM/ATR | |
A011, a potent and selective ataxia-telangiectasia mutated (ATM) inhibitor, exhibits an IC50 of 1.0 nM and triggers apoptosis as well as G2/M phase cell cycle arrest when combined with CPT-11, displaying notable antitumo... |